As an illustration, human SET7/9 has just lately been reported to methylate Lys189 within the general transcription issue TAF10, leading to an elevated affinity for RNA polymerase II and transcriptional activation of sure TAF10-dependent genes 37 SET7/9 has also been reported to methylate p53, rising the stability of this short lived tumor-suppressor protein 38 These observations recommend that we should always not narrowly outline the SET-domain proteins as histone lysine methyltransferases but as an alternative name them protein lysine methyltransferases.

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go.krSpectrometer parameters were as follows: polarity mode, constructive